Disseminated BCG disease in an infant with severe combined immunodeficiency
نویسندگان
چکیده
BCG (Bacillus Calmette Guerin) being a live attenuated vaccine may cause disseminated disease (BCGiosis) in patients with impaired immunity. Patients with severe combined immunodeficiency (SCID) having defect in both cellular and humoral immunity are predisposed to a host of live vaccine related complications, especially BCG. We report an infant presenting persistent fever, weight loss, anemia, hepatosplenomegaly, skin rash and multiple osteolytic lesions subsequently diagnosed with SCID and BCGiosis. The case highlights the possible risk of such rare yet lethal complication of BCG especially where it is given routinely at birth or in the neonatal period and also emphasizes the need for neonatal screening for SCID in such regions. Correspondence to: Anirban Mandal, Department of Pediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi, India Telephone: 8826836670; Email: [email protected]
منابع مشابه
Disseminated Bacille Calmette-Guerin (BCG) disease in an infant with severe combined immunodeficiency.
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